New Agent for Female Sexual Dysfunction Has Promise

The melanocortin-receptor-4-agonist bremelanotide seemed to cut back distress and increase satisfaction among premenopausal ladies with feminine sexual dysfunction, researchers rumored here.

In phase II clinical studies, a 1.75-mg hypodermic dose of the experimental bremelanotide result in a mean reduction of regarding 1.1 points in feminine Sexual Distress Scale-Desire/Arousal/Orgasm score compared with a mean reduction of regarding 0.6 points among placebo patients (P<0.001), said Sheryl Kingsberg, PhD, from Case Western Reserve University in Cleveland, and colleagues.

Combining the 1.25-mg dose and also the 1.75-mg dose, the reduction was regarding 0.9 points (P<0.01 versus placebo), Kingsberg unhappy at an advertisement presentation at the American College of Obstetricians and Gynecologists annual meeting.

"There aren't any approved medication for hypoactive sexual desire disorder in ladies," she told MedPage these days.

"Female sexual dysfunction could be a category of disorders that represent the foremost outstanding sexual disorders in ladies," she went on to clarify. "You could still have sex and it would be pleasurable, but it is about wanting sex."

In a companion study that specifically checked out hypoactive sexual desire disorder, David Portman, MD, director of the Columbus Center for Women's Health analysis in Ohio, said that treatment with bremelanotide resulted in ladies boosting the amount of satisfactory sexual events in a month.

The study by Kingsberg's cluster targeted on the analysis of how at-home, self-administered bremelanotide mitigated the strain hooked up to hypoactive sexual desire.

"The FDA needs that the treatment cut back stress on the feminine Sexual Distress Scale-Desire/Arousal/Orgasm," Kingsberg same. "We demonstrated a dose-dependent efficacy for bremelanotide to cut back the distress of feeling fazed by low sexual desire."

The 12-week study had 97 ladies who were randomised to received placebo, 87 ladies who were treated with a 0.75 mg dose of bremelanotide, that was a dose that wasn't more practical than placebo, 75e ladies who were treated with 0.25 mg of bremelanotide, and 74 ladies on a high dose of 0.75 mg. the ladies self-administered the drug on an as-needed basis.

Responder rates for satisfying sexual events were 37 for placebo, 38% for 0.75-mg dose, 48% for 1.25-mg dose, 55% for 1.75-mg dose, and 51 for one.25-mg and 0.75-mg pooled dose. Responder rates were 45%’ 49%, 60%, 69%, and 64%, severally, on the feminine Sexual Distress Scale-Desire/Arousal/Orgasm.

Patients taking bremelanotide reported more nausea, flushing, and headaches than those on placebo. About 5% of the placebo patients and 10% of the 1.75-mg dose of bremelanotide patients withdrew from the study because of adverse events, but the drug was generally well tolerated, Kingsberg said.

"Bremelanotide has finished its phase II studies and designs for phase III are now awaiting approval from the FDA," she said.

In the phase IIB, 24-week study by Portman's group, women self-administered the drug about 45 minutes prior to anticipate sexual activity. Of the 327 participants, the majority had either mixed hypoactive sexual desire disorder or female sexual arousal disorder with a primary diagnosis of hypoactive sexual desire disorder.

The mean change in sexual satisfying events with was increased by 0.3 events per month among the 76 placebo patients; by 0.7 events a month among the 62 women assigned to the 1.75-mg dose (P<0.05); and by 0.7 events per month in the 128 patients in the pooled 1.25-mg and 1.75-mg dose (P<0.05).

"In premenopausal hypoactive sexual desire disorder, subcutaneous bremelanotide yielded improvements across all key hypoactive sexual desire disorder measures with robust dose-dependence attaining statistical significance at 1.75 mg," the authors concluded.

Studies Say The Smaller Your Clitoris, The Bigger The Problem

New research published in the Journal of Sexual Medicine (the only kind of medicine) is implying that it might not be the size and shape of the boat that matters, but the size and shape of the dock. That metaphor makes little sense, but come on board anyway. What I mean is: when it comes to female orgasm, size matters - clitoral size that is.

The vagina scientists used MRIs to scan 30 women’s’ pelvises. Of those women in the very tiny sample, ten had reported rarely or never achieving orgasm despite their best sexual and masturbatory efforts, the rest had what The Daily Mail referred to as “a normal experience during sex.” I’m not sure what a normal sexual experience is, but using context clues, I figured it means they had orgasms regularly.

Here is what the researchers found: “Although adequate sexual function is complex, we document that clitoral size and location may be paramount in impacting sexual function, specifically orgasm.”

The clit may look like a little button nugget outside the body, but the whole clitoral complex is the boomerang shapes and extends into the body “and includes parts that are known as the body, crura, bulb and root.” The research implies that perhaps the smaller the distance between the whole clitoral-boomerang and the vagina makes orgasming more likely because the clitoris is more easily stimulated during vaginal intercourse. Basically, it could be that the smaller and farther and from the vagina, the less likely a lady is to come.

The team acknowledges that “these physical characteristics cannot be changed,” but that doesn’t mean progress isn’t being made, “understanding the physiology of the female sexual response advances knowledge.” Knowledge is good!

This discovery is pretty freaking cool for a number of reasons. Because it focuses on female parts for once, values female pleasure and could lead to treatments for women afflicted with anorgasmia, the inability to have an orgasm and other types of sexual dysfunction. This is progress, people. I see a future with no gods, no masters, and orgasms for everyone.

Source: http://www.blisstree.com/2014/02/21/sex-relationships/sex/clitoris-orgasm/#ixzz2uKnezVHR